
Advancing our understanding of the mechanisms that govern organelle and lipid homeostasis in health and disease
The Olzmann research group employs a combination of systems biology, chemical biology, and cell biology strategies to elucidate the principles of organelle biogenesis and lipid homeostasis. We are particularly interested in understanding the regulation and functions of neutral lipid storage organelles called lipid droplets. Dysregulation of lipid droplets and lipid metabolism has been implicated in the pathogenesis of numerous diseases, including prevalent metabolic diseases (e.g. obesity and fatty liver disease) and cancer. We are also interested in dissecting the cellular mechanisms that prevent lipotoxic damage, such as the accumulation of oxidatively damaged phospholipids that occurs during ferroptosis. Leveraging genetic approaches, we identify ferroptosis resistance factors that can be therapeutically targeted as a potential new strategy to treat therapy-resistant forms of cancer.
RECENT NEWS
April 1, 2022
Welcome to Irene Lasheras Otero, visiting scholar from the Navarrabiomed in Spain. Happy to have you here!
February 7, 2022
Lipid Droplet Knowledge paper is published in Developmental Cell.
September 30, 2021
Congrats to Melissa on receiving the best poster award at the recent MCB CDB division retreat! Awesome!
September 16, 2021
Olzmann perspective on metabolism research in Molecular Cell Voices article, part of special issue on Metabolism
RECENT ARTICLES

Bersuker et al.
Dev Cell 2018
Bersuker et al.
Nature 2019

Olzmann & Carvalho
Nature Rev Mol Cell Biol 2019
