Advancing our understanding of the mechanisms that govern organelle and lipid homeostasis in health and disease

The Olzmann research group employs a combination of systems biology, chemical biology, and cell biology strategies to elucidate the principles of organelle biogenesis and lipid homeostasis. We are particularly interested in understanding the regulation and functions of neutral lipid storage organelles called lipid droplets. Dysregulation of lipid droplets and lipid metabolism has been implicated in the pathogenesis of numerous diseases, including prevalent metabolic diseases (e.g. obesity and fatty liver disease) and cancer. We are also interested in dissecting the cellular mechanisms that prevent lipotoxic damage, such as the accumulation of oxidatively damaged phospholipids that occurs during ferroptosis. 

RECENT NEWS

June 12, 2021

Clark, Kirandeep, and Milton's Optimized protocol for the identification of lipid droplet proteomes using proximity labeling proteomics is now online in STAR Protocols. Congrats!


June 10, 2021

Joe Hendricks is the recipient of a 2021-22 University of California Cancer Research Coordinating Committee (CRCC) predoctoral fellowship award. Congrats, Joe!

May 12, 2021

Congratulations to our graduating seniors, Emilee Easter and Barbara Shvareva! We will miss you and wish you all the best!    

May 8, 2021

Welcome to Abby Harris, a new graduate student from the Molecular & Cell Biology program!  

April 1, 2021

Welcome to our new postdoc, Mike Lange!!! 

December 20, 2020

Congratulations to Dr. Clark Peterson on the completion of his Ph.D. thesis! 

December 01, 2020

James's award essay "Diversity through equity and inclusion: The responsibility belongs to all of us" is out in Molecular Biology of the Cell.

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RECENT ARTICLES

Bersuker et al.

Dev Cell 2018

Develops a proximity labeling proteomic approach to define high confidence lipid droplet proteomes

Bersuker et al.

Nature 2019

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Identification of the CoQ oxidoreductase FSP1 as a ferroptosis suppressor in cancer

Olzmann & Carvalho

Nature Rev Mol Cell Biol 2019

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Review of lipid droplet biogenesis and cellular functions