Advancing our understanding of the mechanisms that govern organelle and lipid homeostasis in health and disease

The Olzmann research group employs a combination of systems biology, chemical biology, and cell biology strategies to elucidate the principles of organelle biogenesis and lipid homeostasis. We are particularly interested in understanding the regulation and functions of neutral lipid storage organelles called lipid droplets. Dysregulation of lipid droplets and lipid metabolism has been implicated in the pathogenesis of numerous diseases, including prevalent metabolic diseases (e.g. obesity and fatty liver disease) and cancer. We are also interested in dissecting the cellular mechanisms that prevent lipotoxic damage, such as the accumulation of oxidatively damaged phospholipids that occurs during ferroptosis. Leveraging genetic approaches, we identify ferroptosis resistance factors that can be therapeutically targeted as a potential new strategy to treat therapy-resistant forms of cancer.

RECENT NEWS

September 30, 2021

Congrats to Melissa on receiving the best poster award at the recent MCB CDB division retreat! Awesome!


September 16, 2021

Olzmann perspective on metabolism research in Molecular Cell Voices article, part of special issue on Metabolism

August 31, 2021

Congrats to Dr. Sarah Morris on the completion of her thesis and graduation! PhD!

June 12, 2021

Clark, Kirandeep, and Milton's Optimized protocol for the identification of lipid droplet proteomes using proximity labeling proteomics is now online in STAR Protocols. Congrats!


June 10, 2021

Joe Hendricks is the recipient of a 2021-22 University of California Cancer Research Coordinating Committee (CRCC) predoctoral fellowship award. Congrats, Joe!

May 12, 2021

Congratulations to our graduating seniors, Emilee Easter and Barbara Shvareva! We will miss you and wish you all the best!    

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RECENT ARTICLES

Bersuker et al.

Dev Cell 2018

Develops a proximity labeling proteomic approach to define high confidence lipid droplet proteomes

Bersuker et al.

Nature 2019

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Identification of the CoQ oxidoreductase FSP1 as a ferroptosis suppressor in cancer

Olzmann & Carvalho

Nature Rev Mol Cell Biol 2019

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Review of lipid droplet biogenesis and cellular functions