Advancing our understanding of the mechanisms that govern organelle and lipid homeostasis in health and disease

The Olzmann research group employs a combination of systems biology, chemical biology, and cell biology strategies to elucidate the principles that regulate organelle biology and cellular lipid homeostasis. We are particularly interested in understanding the regulation and functions of neutral lipid storage organelles called lipid droplets. Dysregulation of lipid droplets and lipid metabolism has been implicated in the pathogenesis of numerous diseases, including prevalent metabolic diseases (e.g. obesity and fatty liver disease) and cancer. We are also interested in dissecting the cellular mechanisms that prevent lipotoxic damage, such as the accumulation of oxidatively damaged phospholipids during ferroptosis. Leveraging chemical-genetic approaches, we seek to define ferroptosis resistance mechanisms that can be therapeutically targeted as a strategy to treat therapy-resistant forms of cancer.

RECENT NEWS

November 30, 2022
Congrats to Sarah Siti Nur Morris and team on the publication of her manuscript "A genome-wide CRISPR screen implicates plasma membrane asymmetry in exogenous C6-ceramide toxicity" in Biology Open!

August 29, 2022
Congrats to Melissa Roberts and team on the publication of her manuscript "Parallel CRISPR-Cas9 screens reveal mechanisms of PLIN2 and lipid droplet regulation" on bioRxiv!

August 29, 2022
Congrats to Melissa Roberts and team on the launch of CRISPRlipid, a new data commons for functional genomic screens related to lipid biology!

June 23, 2022
Congrats to Melissa Roberts on the publication of her collaborative paper with the Ferro-Novick lab "VPS13A and VPS13C influence lipid droplet abundance" on bioRxiv.

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RECENT ARTICLES

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Li et al.
Nature Chem Biol 2022

Bersuker et al.

Nature 2019

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Olzmann & Carvalho

Nature Rev Mol Cell Biol 2019

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Reveals selenium metabolism and ribosome stalling as ferroptosis vulnerabilities

Identifies the CoQ oxidoreductase FSP1 as a powerful ferroptosis suppressor in cancer

Review of lipid droplet biogenesis and cellular functions