Advancing our understanding of the mechanisms that govern organelle and lipid homeostasis in health and disease

The Olzmann research group employs a combination of systems biology, chemical biology, and cell biology strategies to elucidate the principles that regulate organelle biology and cellular lipid homeostasis. We are particularly interested in understanding the regulation and functions of neutral lipid storage organelles called lipid droplets. Dysregulation of lipid droplets and lipid metabolism has been implicated in the pathogenesis of numerous diseases, including prevalent metabolic diseases (e.g. obesity and fatty liver disease) and cancer. We are also interested in dissecting the cellular mechanisms that prevent lipotoxic damage, such as the accumulation of oxidatively damaged phospholipids during ferroptosis. Leveraging chemical-genetic approaches, we seek to define ferroptosis resistance mechanisms that can be therapeutically targeted as a strategy to treat therapy-resistant forms of cancer.

RECENT NEWS

June 23, 2022
Congrats to Melissa Roberts on the publication of her collaborative paper with the Ferro-Novick lab "VPS13A and VPS13C influence lipid droplet abundance" on bioRxiv.

May 30, 2022
Congrats to Zhipeng Li on the publication of his paper "Ribosome stalling during selenoprotein translation exposes a ferroptosis vulnerability" in Nature Chemical Biology!

April 1, 2022

Welcome to Irene Lasheras Otero, visiting scholar from the Navarrabiomed in Spain. Happy to have you here! 

February 7, 2022

Lipid Droplet Knowledge paper is published in Developmental Cell. 

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RECENT ARTICLES

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Li et al.
Nature Chem Biol 2022

Bersuker et al.

Nature 2019

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Olzmann & Carvalho

Nature Rev Mol Cell Biol 2019

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Reveals selenium metabolism and ribosome stalling as ferroptosis vulnerabilities

Identifies the CoQ oxidoreductase FSP1 as a powerful ferroptosis suppressor in cancer

Review of lipid droplet biogenesis and cellular functions