Advancing our understanding of the mechanisms that govern organelle and lipid homeostasis in health and disease
The Olzmann research group employs a combination of systems biology, chemical biology, and cell biology strategies to elucidate the principles of organelle biogenesis and lipid homeostasis. We are particularly interested in understanding the regulation and functions of neutral lipid storage organelles called lipid droplets. Dysregulation of lipid droplets and lipid metabolism has been implicated in the pathogenesis of numerous diseases, including prevalent metabolic diseases (e.g. obesity and fatty liver disease) and cancer. We are also interested in dissecting the cellular mechanisms that prevent lipotoxic damage, such as the accumulation of oxidatively damaged phospholipids that occurs during ferroptosis.
RECENT NEWS
October 19, 2020
Emilee receives a grant from the Cayman Biomedical Research Institute. Congrats!
May 02, 2020
Congratulations to Dr. Milton To on the completion of his thesis! We will miss you and we wish you all the best at your new position as a Scientist at Amunix!
RECENT ARTICLES

Bersuker et al.
Dev Cell 2018
Develops a proximity labeling proteomic approach to define high confidence lipid droplet proteomes
Bersuker et al.
Nature 2019

Identification of the CoQ oxidoreductase FSP1 as a ferroptosis suppressor in cancer
Olzmann & Carvalho
Nature Rev Mol Cell Biol 2019
