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Selenium reduction of ubiquinone via SQOR suppresses ferroptosis

Lee, N., Park, S.J., Lange, M., Tseyang, T., Doshi, M., Kwon, T.Y., Song, Y., Greer, P.L., Olzmann, J.A., Spinelli, J., Kim, D. (Accepted in Principle)

bioRxiv link posted 04.13.2023


Small molecule correctors divert CFTR-F508del from ERAD by stabilizing sequential folding states

Riepe, C., Wachalska, M., Deol, K.K. Amaya, K. Porteus, M.H., Olzmann, J.A., Kopito, R.R. Molecular Biology of the CellOnline ahead of print. 

bioRxiv link posted 09.16.2023


Lipid quality control and ferroptosis: From concept to mechanism

 Li, Z.*, Lange, M.*, Dixon, S.J., Olzmann, J.A. Annual Review of Biochemistry. Online ahead of print.


A cell cycle-dependent ferroptosis sensitivity switch governed by EMP2

Rodencal, J., Stahlhut, C., Kim, N., Li, V.L., He, A., Lange, M., He, J., Tarangelo, A., Schafer, Z.T., Olzmann, J.A., Sage, J., Long, J.Z., Beltran, P., Dixon, S.J.

Cell Chemical Biology. 31, 1-15. Online ahead of print.

bioRxiv link posted 07.19.2023


Parallel CRISPR-Cas9 screens reveal mechanisms of PLIN2 and lipid droplet regulation

Roberts, M.A., Deol, K.K., Lange, M., Leto, D., Mathiowetz, A.J., Stevenson, J., Hashemi, S.H., Morgens, D.W., Easter, E., Heydari, K., Nalls, M.A., Bassik, M.C., Kampmann, M., Kopito, R.R., Faghri, F., Olzmann, J.A.

Developmental Cell. (2023) S1534-5807(23)00331-3.

bioRxiv link posted 08.29.2022


Identification of structurally diverse FSP1 inhibitors that sensitize cancer cells to ferroptosis

Hendricks, J.M., Doubravsky, C.E., Wehri, E., Li, Z., Roberts, M.A., Deol, K.K., Lange, M., Lasheras-Otero, I., Momper, J.D., Dixon, S.J., Bersuker, K., Schlatetzky, J.#, Olzmann, J.A.#

Cell Chemical Biology. (2023) 4;S2451-9456(23)00114-9.

bioRxiv link posted 12.14.2022

Featured in Preview by da Silva and Friedmann Angeli (Cell Chem Biol 2023)


Protocol for performing pooled CRISPR-Cas9 loss of function screens to identify genetic modifiers

Mathiowetz, A.J.*, Roberts, M.A.*, Morgens, D.W., Olzmann, J.A.#, Li, Z.# 

STAR Protocols. (2023) 4(2):102201.


Hydropersulfides are endogenous antioxidants that inhibit ferroptosis

Lange, M. and Olzmann, J.A.

Cell Chemical Biology. (2022) 29(12):1661-1663.


A genome-wide CRISPR screen implicates plasma membrane asymmetry in exogenous C6-ceramide toxicity

Morris, S.N.S., Deol, K.K., Lange, M., Olzmann, J.A.

Biology Open. (2022) 11(12):bio059695.

bioRxiv link posted 09.28.2022


VPS13A and VPS13C influence lipid droplet abundance

Chen, S.*, Roberts, M.A.*, Chen, C.Y., Markmiller, S., Wei, H.G., Yeo, G.W., Granneman, J.G., Olzmann, J.A.#, Ferro-Novick, S.#

Contact. (2022) 5, 1-7.

bioRxiv link posted 06.23.2022


Context-dependent regulation of ferroptosis sensitivity

Magtanong, L., Mueller, G.D., Williams, K.J., TKO Lab, Andrews, B., Boone, C., Moffat, J., Olzmann, J.A., Bensinger, S.J., Dixon, S.J.

Cell Chemical Biology. (2022) S2451-9456(22)00236-7.

– Featured in Preview by Lee and Gan (Cell Chem Biol. 2022)


End of the road: From the ER to the proteasome

Olzmann, J.A.​

Nature Review of Molecular and Cell Biology. (2022) 23(8):520.


Ribosome stalling during selenoprotein translation exposes a ferroptosis vulnerability

Li., Z., Ferguson, L., Deol, K.K., Roberts, M.A., Magtanong, L., Hendricks, J.M., Mousa, G.A., Kilinc, S., Schaefer, K., Wells, J.A., Bassik, M.C., Goga, A., Dixon, S.J., Ingolia, N., Olzmann, J.A.​

Nature Chemical Biology. (2022) 18(7):751-761.

bioRxiv link posted 04.11.2022

Featured in Research Watch (Cancer Discovery. 2022)


The Lipid Droplet Knowledge Portal: A resource for systematic analyses of lipid droplet biology

Mejhert N., Gabriel, K.R., Frendo-Cumbo, S., Krahmer, N., Song, J., Kuruvilla, L., Chitraju, C., Boland, S., Jang, D.K., von Grotthuss, M., Costanzo, M.C., Ryden, M., Olzmann, J.A., Flannick, J., Burtt, N.P., Farese, R.V., Walther, T.C.

Developmental Cell. (2022) 57, 387–397.


More Metabolism!

Olzmann, J.A., Fendt, S.M., Shah, Y., Vousden, K., Chandel, N., Horng, T., Danial, N., Tu, B., Christofk, H., Vander Heiden, M.G., Wellen, K.

Molecular Cell. (2021) 81(18):3659-3664.


Ending on a sour note: Lipids orchestrate ferroptosis in cancer

Lange, M., Olzmann, J.A.​

Cell Metabolism. (2021) 33(8):1507-1509.


Optimized protocol for the identification of lipid droplet proteomes using proximity labeling proteomics in cultured human cells

Peterson, C.W.H.*, Deol, K.K.*, To, M., Olzmann, J.A.

STAR Protocols. (2021) 5;2(2):100579.


Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

Klionsky, D. ... Olzmann, J.A., et al.

Autophagy. (2021) 17(1):1-382.


Diversity through equity and inclusion: The responsibility belongs to all of us

Olzmann, J.A.

Molecular Biology of the Cell. (2020) 31(25):2757-2760.


Protein quality control and lipid droplet metabolism

Roberts, M.A., Olzmann, J.A.

Annual Review of Cell Developmental Biology. (2020) 36:115-139.


Organelle biogenesis: ER shape influences lipid droplet nucleation

Roberts, M.A., Segura-Roman, A., Olzmann, J.A.

Current Biology. (2020) 30(13), R770–R773.


Going through a phase

Li, Z., Morris, S.N.S., Olzmann, J.A.

Nature Chemical Biology. (2020) 16(2):111-112.


Covalent targeting of the vacuolar H+-ATPase enhances cellular clearance through inhibition of lysosomal mTORC1 signaling

Chung C.Y.S., Shin, H.R., Berdan, C.A., Ford, B., Ward, C.C., Olzmann J.A., Zoncu, R., Nomura, D.K.

Nature Chemical Biology. (2019) 15(8):776-785.


A tense situation: Maintaining ER homeostasis during lipid droplet budding

Morris, S.N.S., Olzmann, J.A.

Developmental Cell. (2019) 50, 1-2.


Harnessing the anti-cancer natural product nimbolide for targeted protein degradation

Spradlin, J.N., Hu, X., Ward, C.C., Brittain, S.M., Jones, M.D., Ou, L., To, M., Proudfoot, A., Ornelas, E., Woldegiorgis, M., Olzmann, J.A., Bussiere, D.E., Thomas, J.R., Tallarico, J.A., McKenna, J.M., Schirle, M., Maimone, T.J., Nomura, D.K.

Nature Chemical Biology. (2019) 15(7):747-755.

– Featured in News & Views by Brand and Winter (Nat. Chem. Biol. 2019)


Identification of lipid droplet proteomes by proximity labeling proteomics using APEX2

Bersuker, K., Olzmann, J.A.

Methods Molecular Biology. - Proximity Labeling. (2019) 57-72.


Parthenolide impairs breast cancer pathogenicity through targeting an allosteric cysteine on focal adhesion kinase

Berdan, C.A., Ho, R., Lehtola, H.S., To, M., Hu, X., Huffman, T.R., Petri, Y., Altobelli, C.R., Demeulenaere, S.G., Olzmann, J.A., Maimone, T.J., Nomura, D.K.

Cell Chemical Biology. (2019) 26(7):1027-1035.


Getting a handle on lipid droplets: Insights into ER-lipid droplet tethering

Nguyen, T., Olzmann J.A.

Journal of Cell Biology. (2019) 218(4):1089-1091.


Exogenous monounsaturated fatty acids suppress non-apoptotic cell death

Magtanong, L., Ko, P.J., To, M., Cao, J.Y., Tarangelo, A.N., Ward, C., Nomura, D.K., Olzmann, J.A., Dixon, S.

Cell Chemical Biology. (2019) 26, 420–432.

–  Featured in Preview by Undurti Das (Cell Chem. Biol., 26, 309-311)


Dynamics and functions of lipid droplets

Olzmann, J.A., Carvalho, P.

Nature Review of Molecular and Cell Biology. (2019) 20(3): 137-155.


A proteomic map to navigate subcellular reorganization in fatty liver disease

Li, Z., Olzmann, J.A.

Developmental Cell. (2018) 47, 139-141.


In close proximity: The lipid droplet proteome and crosstalk with the ER

Bersuker, K, Olzmann, J.A.

Contact. (2018) (1), 1-3.


A VCP inhibitor substrate trapping approach (VISTA) enables proteomic profiling of endogenous ERAD substrates

Huang, E.Y.*, To, M.*, Tran, E., Dionisio, L., Cho, H.J., Baney, K.L.M., Pataki, C.I., Olzmann, J.A.

Molecular Biology of the Cell. (2018) 29(9), 1021-1030.


A proximity labeling strategy provides insights into the composition and dynamics of lipid droplet proteomes

Bersuker, K., Peterson, C.W., To, M., Sahl, S.J., Savikhin, V., Grossman, E.A., Nomura, D.K., Olzmann, J.A.

Developmental Cell. (2018) 44, 97-112.

–  Featured in Preview by Joel Goodman (Dev. Cell, 44, 1-2)


Chemoproteomics-Enabled Covalent Ligand Screening Reveals a Thioredoxin-Caspase 3 Interaction Disruptor That Impairs Breast Cancer Pathogenicity

Anderson, K.E., To, M., Olzmann, J.A., Nomura, D.K.

ACS Chemical Biology. (2017) 12(10), 2522-2528.


Lipid droplets and lipotoxicity during autophagy

Nguyen, T.B., Olzmann, J.A.

Autophagy. (2017) 13:11, 2002-2003.


Establishing the lipid droplet proteome: Mechanisms of lipid droplet protein targeting and degradation

Bersuker, K., Olzmann, J.A.

BBA - Molecular and Cell Biology of Lipids. (2017) 1862(10 Pt B), 1166-1177.


Characterization of protein complexes of the endoplasmic reticulum associated degradation E3 ubiquitin ligase Hrd1

Hwang, J., Walczak, C.P., Shaler, T.A., Olzmann, J.A., Zhang, L., Elias, J.E., Kopito, R.R.

Journal of Biological Chemistry. (2017) 292, 9104-9116.


Chemoproteomics-enabled covalent ligand screen reveals a cysteine hotspot in Reticulon 4 that impairs ER morphology and cancer pathogenicity

Bateman, L.A.*, Nguyen, T.B.*, Roberts, A.M.*, Miyamoto, D.K., Ku, W.M., Huffman, T.R., Petri, Y., Heslin, M.J., Contreras, C.M., Skibola, C.F., Olzmann, J.A.#, Nomura, D.K.#

# indicates co-corresponding authors

Chemical Communications. (2017) Jun 29;53(53), 7234-7237.


Lipid disequilibrium disrupts ER proteostasis by impairing ERAD substrate glycan trimming and dislocation

To, M.*, Peterson, C.W.*, Roberts, M.A., Counihan, J.L., Wu, T.T., Forster, M.S., Nomura, D.K., Olzmann, J.A.​

Molecular Biology of the Cell. (2017) (28), 270-284.


Endoplasmic reticulum-associated degradation and lipid homeostasis

Stevenson, J.*, Huang, E.Y.*, Olzmann, J.A.

Annual Review of Nutrition. (2016) 36, 17.1–17.32.


A polyubiquitin chain reaction: Parkin recruitment to damaged mitochondria

Riley, B.E., Olzmann, J.A.

PLOS Genet. (2015) 11(1), e1004952.


Spatial regulation of UBXD8 and p97/VCP controls ATGL-mediated lipid droplet turnover

Olzmann, J.A., Richter, C.R., Kopito, R.R.

Proc. Natl. Acad. Sci. (2013) 110(4), 1345-50.


The mammalian endoplasmic reticulum-associated degradation system

Olzmann, J.A., Kopito, R.R., Christianson, J.C.

Cold Spring Harb. Perspect. Biol. (2013) cshperspect.a013185v1. 1;5(9), pii: a013185.


Unassembled CD147 is an endogenous ER-associated degradation (ERAD) substrate

Tyler, R.E., Pearce, M.M.P., Shaler, T.A., Olzmann, J.A., Greenblatt, E.J., Kopito, R.R.

Molecular Biology of the Cell. (2012) 23(24), 4668-78.


Making the cut: Intramembrane cleavage by a rhomboid protease promotes ERAD

Greenblatt, E.J., Olzmann, J.A., Kopito, R.R.

Nature Structural and Molecular Biology. (2012) 19(10), 979-981.


Defining human ERAD networks through an integrated mapping strategy

Christianson, J.C.*, Olzmann, J.A.*, Shaler, T.A., Sowa, M.E., Bennett, E.J., Richter, C.M., Tyler, R.E., Greenblatt, E.J., Harper, J.W., Kopito, R.R.

* These authors contributed equally

Nature Cell Biology. (2012) 14(1), 93-105.

–  Featured in News and Views by Thibault Mayor (Nat Cell Biol 14(1), 46-47)


Derlin-1 is a rhomboid protein required for dislocation of mutant a-1-antitrypsin from the endoplasmic reticulum

Greenblatt, E.J., Olzmann, J.A., Kopito, R.R.

Nature Structural and Molecular Biology. (2011) 18(10), 1147-1152.


Lipid droplets are dispensable for endoplasmic reticulum-associated degradation

Kopito, R.R., Olzmann, J.A.

Journal of Biological Chemistry. (2011) 286, 27872-27874.


Parkin-mediated ubiquitin signaling in aggresome formation and autophagy

Chin, L.S., Olzmann, J.A., Li, L.

Biochem. Soc. Trans. (2010) 48(1), 144-149.


SPFH1 and SPFH2 mediate the ubiquitination and degradation of inositol 1,4,5-trisphosphate receptors in muscarinic receptor-expressing HeLa cells

Wang, Y., Pearce, M.M., Sliter, D.A., Olzmann, J.A., Christianson, J.C., Kopito, R.R., Boeckmann, S., Gagen, C., Leichner, G.S., Roitelman, J., Wojcikiewicz, R.J.

Biochim. Biophys. Acta. (2009) 1793(11), 1710-8.


Corneal dystrophy-associated R124H mutation disrupts TGFBI interaction with Periostin and causes mislocalization to the lysosome

Kim, B.Y., Olzmann, J.A., Choi, S.I., Ahn, S.Y., Kim, T.I., Cho, H.S., Suh, H., Kim, E.K.

Journal of Biological Chemistry. (2009) 284,19580-19591.


Aggresome formation and neurodegenerative diseases: therapeutic implications

Olzmann, J.A., Li, L., Chin, L.S.

Current Medicinal Chemistry. (200) 15(1), 47-60.


Parkin-mediated K63-linked polyubiquitination targets misfolded DJ-1 to aggresomes via binding HDAC6

Olzmann, J.A., Li, L., Chudaev, M., Perez, F.A., Palmiter, R. D., Chin, L.S.

Journal of Cell Biology. (2007) 178, 1025-1038.


Spongiform neurodegeneration-associated E3 ligase Mahogunin ubiquitylates TSG101 and regulates endosomal trafficking

Kim, B.Y.*, Olzmann, J.A.*, Barsh, G.S., Chin, L.S., Li, L.

* These authors contributed equally

Molecular Biology of the Cell. (2007) 18, 1129-1142.


Selective enrichment of DJ-1 protein in primate striatal neuronal processes: Implications for Parkinson’s disease

Olzmann, J.A., Bordelon, J.R., Muly, E.C., Rees, H.D., Levey, A.I., Li, L, Chin, L.S.

Journal of Comparative Neurology. (2007) 500, 585-599.


Oxidative damage of DJ-1 is linked to sporadic Parkinson's and Alzheimer's diseases

Choi, J., Sullards, C. M., Olzmann, J. A., Rees, H. D., Weintraub, S. T., Bostwick, D. E., Gearing, M., Levey, A. I., Chin, L. S., Li, L.

Journal of Biological Chemistry. (2006) 281, 10816-24.


Uncoupling proteins prevent glucose-induced neuronal oxidative stress and programmed cell death

Vincent, A. M., Olzmann, J. A., Brownlee, M., Sivitz, W. I., and Russell, J. W.

Diabetes. (2004) 53, 726-734.


Familial Parkinson's disease-associated L166P mutation disrupts DJ-1 protein folding and function

Olzmann, J.A., Brown, K., Wilkinson, K. D., Rees, H. D., Huai, Q., Ke, H., Levey, A. I., Li, L., and Chin, L. S.

Journal of Biological Chemistry. (2004) 279, 8506-8515.


High glucose-induced oxidative stress and mitochondrial dysfunction in neurons

Russell, J. W., Golovoy, D., Vincent, A. M., Mahendru, P., Olzmann, J.A., Mentzer, A., and Feldman, E. L.

FASEB Journal. (2002) 16, 1738-1748. 

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