Protein quality control and lipid droplet metabolism.

Roberts, M.A. and Olzmann, J.A.

Annual Review of Cell and Developmental Biology. 2020. In Press.​

Organelle biogenesis: ER shape influences lipid droplet nucleation.

Roberts, M.A., Segura-Roman, A., and Olzmann, J.A.

Current Biology. 2020. 30, R770–R773.​

A genome-wide screen for ER autophagy highlights key roles of mitochondrial metabolism and ER-resident UFMylation.

Liang, J.R.*, Lingeman, E.*, Luong, T., Ahmed, S., Muhar, M., Nguyen, T., Olzmann, J.A., Corn, J.E.

Cell. 2020. 19;180(6):1160-1177.e20. (bioRxiv Preprint posted 02/15/19)

• Featured in Research Highlight from Paulina Strzyz. Nature Reviews Molecular Cell Biology.

• Featured in Spotlight from Maurizio Molinari. Mol Cell.

Going through a phase.

Li, Z., Morris, S.N.S., Olzmann, J.A.

Nature Chemical Biology. 2020. 16(2):111-112.​​​

The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis.

Bersuker, K., Hendricks, J., Li, Z., Magtanong, L., Ford, B., Tang, P., Roberts, M.A., Tong, B., Maimone, T.J., Zoncu, R., Bassik, M.C., Nomura, D., Dixon, S.J., Olzmann, J.A.

Nature. 2019. 575(7784):688-692.​

• Featured in News & Views from Brent Stockwell. Nature. 

• Featured in Research Highlight from Grant Miura. Nature Chemical Biology.

• Featured in Research Highlight from Liang et al. Cell Research.

• Featured in Preview from Massimo Santoro. Cell Metabolism.

• Featured in Viewpoint from Kamyar Hadian. Biochemistry.

Covalent targeting of the vacuolar H+-ATPase enhances cellular clearance through inhibition of lysosomal mTORC1 signaling.

Chung, C.Y-S., Shin, H.R., Berdan, C.A., Ford, B., Ward, C.C. Olzmann, J.A., Zoncu, R., Nomura, D.K.

Nature Chemical Biology. 2019. 15(8):776-785.

• Featured in News & Views by Meng and Jewell. Nature Chemical Biology. 15(8):760-761.

A tense situation: Maintaining ER homeostasis during lipid droplet budding.

Morris, S.N.S. and Olzmann, J.A.

Developmental Cell. 2019. 50, 1-2.

Harnessing the Anti-Cancer Natural Product Nimbolide for Targeted Protein Degradation.

Spradlin, J.N., Hu, X., Ward, C.C., Brittain, S.M., Jones, M.D., Ou, L., To, M., Proudfoot, A., Ornelas, E., Woldegiorgis, M., Olzmann, J.A., Bussiere, D.E., Thomas, J.R., Tallarico, J.A., McKenna, J.M., Schirle, M., Maimone, T.J., Nomura, D.K.

Nature Chemical Biology. 2019. 15(7):747-755. (bioRxiv Preprint posted April 09, 2019)

• Featured in News & Views by Brand and Winter. Nature Chemical Biology. 15(7):655-656.

Identification of Lipid Droplet Proteomes by Proximity Labeling Proteomics Using APEX2.

Bersuker, K. and Olzmann, J.A.

Methods in Molecular Biology: Proximity Labeling. 2019. 2008: 57-72.

Parthenolide covalently targets and inhibits focal adhesion kinase in breast cancer cells.

Berdan, C.A., Ho, R., Lehtola, H.S., To, M., Hu, X., Huffman, T.R., Petri, Y., Altobelli, C.R., Demeulenaere, S.G., Olzmann, J.A., Maimone, T.J., Nomura, D.K.

Cell Chemical Biology. 2019. 26, 1-9. (bioRxiv Preprint posted 02/14/19)

Getting a handle on lipid droplets: Insights into ER–lipid droplet tethering.

Nguyen, T. and Olzmann, J.A.

Journal of Cell Biology. 2019. 218(4):1089-1091.

Exogenous monounsaturated fatty acids suppress non-apoptotic cell death.

Magtanong, L., Ko, P.J., To, M., Cao, J.Y., Tarangelo, A., Ward, C.C., Cho, K.Y., Patti, G.J., Nomura, D.K., Olzmann, J.A., Dixon, S.J.

Cell Chemical Biology. 2019. 26, 420–432

• Featured in Preview by Undurti Das. Developmental Cell. 26, 309-311.

Dynamics and functions of lipid droplets.

Olzmann, J.A. and Carvalho, P.

Nature Reviews Molecular Cell Biology. 2019. 20(3):137-155.

A proteomic map to navigate subcellular reorganization in fatty liver disease.

Li, Z. and Olzmann, J.A.

Developmental Cell. 2018. 47, 139-141.

In close proximity: The lipid droplet proteome and crosstalk with the ER.

Bersuker, K. and Olzmann, J.A.

Contact. 2018. (1) 1-3.

A VCP inhibitor substrate trapping approach (VISTA) enables proteomic profiling of endogenous ERAD substrates.

Huang, E.Y.*, To, M.*, Tran, E., Ador Dionisio, L.T., Cho, H.J., Baney, K.L.M., Pataki, C.I., Olzmann, J.A.

Molecular Biology of the Cell. 2018. 29(9):1021-1030.

• Featured as a "Highlights from MBoC Selection"

• Featured on the cover of the issue

A proximity labeling strategy provides insights into the composition and dynamics of lipid droplet proteomes.

Bersuker, K., Peterson, C.W., To, M., Roberts, E., Sahl, S., Nomura, D.K., Olzmann, J.A.

Developmental Cell. 2018. 44, 97-112. 

• Featured in Preview by Joel Goodman. Developmental Cell. 44, 1-2.

Chemoproteomics-Enabled Covalent Ligand Screening Reveals a Thioredoxin-Caspase 3 Interaction Disruptor That Impairs Breast Cancer Pathogenicity.

Anderson, K.E., To, M., Olzmann, J.A., Nomura, D.K. 

ACS Chemical Biology. 2017. 12(10):2522-2528. 

Lipid droplets and lipotoxicity during autophagy.

Nguyen, T.B. and Olzmann, J.A. 

Autophagy. 2017;13(11):2002-2003.

DGAT1-Dependent Lipid Droplet Biogenesis Protects Mitochondrial Function during Starvation-Induced Autophagy.

Nguyen, T.B., Louie, S.M., Daniele, J., Tran, Q., Dillin, A., Zoncu, R., Nomura, D.K., Olzmann, J.A.

Developmental Cell. 2017 Jul 10;42(1):9-21.e5.

• Featured in Preview by Klecker et al. Developmental Cell. 41, 1-2.

• Featured in Comment by Li et al. Autophagy. 13(11): 1995-1997.

• Featured in Best of Developmental Cell 2017

Establishing the lipid droplet proteome: Mechanisms of lipid droplet protein targeting and degradation.

Bersuker, K. and Olzmann, J.A.

BBA - Molecular and Cell Biology of Lipids. 2017. 1862(10 Pt B):1166-1177. 

Characterization of protein complexes of the endoplasmic reticulum associated degradation E3 ubiquitin ligase Hrd1.

Hwang, J., Walczak, C.P., Shaler, T.A., Olzmann, J.A., Zhang, L., Elias, J.E., Kopito, R.R.

Journal of Biological Chemistry. 2017. Jun 2;292(22):9104-9116. 

Chemoproteomics-enabled covalent ligand screen reveals a cysteine hotspot in Reticulon 4 that impairs ER morphology and cancer pathogenicity.

Bateman, L.A.*, Nguyen, T.B.*, Roberts, A.M.*, Miyamoto, D.K., Ku, W.M., Huffman, T.R., Petri, Y., Heslin, M.J., Contreras, C.M., Skibola, C.F., Olzmann, J.A.#, Nomura, D.K.# (# indicates co-corresponding)

Chemical Communications. 2017. Jun 29;53(53):7234-7237.

Lipid disequilibrium disrupts ER proteostasis by impairing ERAD substrate glycan trimming and dislocation.

To, M.*, Peterson, C.W.*, Roberts, M.A., Counihan, J.L., Wu, T.T., Forster, M.S., Nomura, D.K., Olzmann, J.A.

Molecular Biology of the Cell. 2017. Jan 15;28(2):270-284.

Endoplasmic reticulum-associated degradation and lipid homeostasis.

Stevenson, J., Huang, E.Y., Olzmann, J.A.

Annual Review of Nutrition. 2016. Jul 17;36:511-42.

A polyubiquitin chain reaction: Parkin recruitment to damaged mitochondria.

Riley, B.E. and Olzmann, J.A.

PLoS Genetics. 2015. Jan 22;11(1):e1004952.

Spatial regulation of UBXD8 and p97/VCP controls ATGL-mediated lipid droplet turnover.

Olzmann, J.A., Richter, C.M., Kopito, R.R.

Proc Natl Acad Sci U S A. 2013. Jan 22;110(4):1345-50.

The mammalian endoplasmic reticulum-associated degradation system.

Olzmann, J.A., Kopito, R.R., Christianson, J.C.

Cold Spring Harb Perspect Biol. 2013. Sep 1;5(9). pii: a013185.

Unassembled CD147 is an endogenous endoplasmic reticulum-associated degradation substrate.

Tyler, R.E., Pearce, M.M., Shaler, T.A., Olzmann, J.A., Greenblatt, E.J., Kopito, R.R.

Molecular Biology of the Cell. 2012. Dec;23(24):4668-78.

Defining human ERAD networks through an integrative mapping strategy.

Christianson, J.C.*, Olzmann, J.A.*, Shaler, T.A., Sowa, M.E., Bennett, E.J., Richter, C.M., Tyler, R.E., Greenblatt, E.J., Harper, J.W., Kopito, R.R. * Equal contribution

Nature Cell Biology. 2011. Nov 27;14(1):93-105.

• Featured in News & Views by Thibault Mayor. Nature Cell Biology. 2011. Dec 22;14(1):46-7

Derlin-1 is a rhomboid protein required for dislocation of mutant alpha-1-antitrypsin from the endoplasmic reticulum.

Greenblatt, E.J., Olzmann, J.A., Kopito, R.R.

Nature Structural and Molecular Biology. 2011. 18(10), 1147-1152.​

Charcot-Marie-Tooth disease-associated mutations cause SIMPLE protein mislocalization and degradation by the proteasome and aggresome-autophagy pathways.

Lee, S.M., Olzmann, J.A., Chin, L.S., Li, L.

Journal of Cell Science. 2011. 124, 3319-3331.

Lipid droplets are dispensable for endoplasmic reticulum-associated degradation.

Olzmann, J.A., Kopito, R.R.

Journal of Biological Chemistry. 2011. 286, 27872-27874.

Parkin-mediated ubiquitin signaling in aggresome formation and autophagy.

Chin, L.S., Olzmann, J.A., Li, L.

Biochem. Soc. Trans. 2010. 48(1), 144-149.

An ER membrane complex composed of SPFH1 and SPFH2 mediates the ER-associated degradation of IP3 receptors.

Wang, Y., Pearce, M.M., Sliter, D.A., Olzmann, J.A., Christianson, J.C., Kopito, R.R., Boeckmann, S., Gagen, C., Leichner, G.S., Roitelman, J., Wojcikiewicz, R.J.

Biochim. Biophys. Acta. 2009. 1793(11), 1710-8.

Corneal dystrophy-associated R124H mutation disrupts TGFBI interaction with Periostin and causes mislocalization to the lysosome.

Kim, B.Y., Olzmann, J.A., Choi, S.I., Ahn, S.Y., Kim, T.I., Cho, H.S., Suh, H., Kim, E.K.

Journal of Biological Chemistry. 2009. 284,19580-19591.

Aggresome formation and neurodegenerative diseases: therapeutic implications.

Olzmann, J.A., Li, L., Chin, L.S.

Curr. Med. Chem. 2008.15(1), 47-60.

Parkin-mediated K63-linked polyubiquitination: a signal for targeting misfolded proteins to the aggresome-autophagy pathway.

Olzmann, J.A., Chin, L.S.

Autophagy. 2008. 4(1), 85-87.

Parkin-mediated K63-linked polyubiquitination targets misfolded DJ-1 to aggresomes via binding HDAC6.

Olzmann, J.A., Li, L., Chudaev, M., Perez, F.A., Palmiter, R. D., Chin, L.S.

Journal of Cell Biology. 2007. 178, 1025-1038.

PINK1 protects against oxidative stress-induced apoptosis by phosphorylating mitochondrial chaperone TRAP1/Hsp75.

Pridgeon, J.W.*, Olzmann, J.A.*, Chin, L.S., Li, L. * Equal contribution.

PLoS Biology. 2007. 5, e172.

• Featured in News and Views by Asa Abeliovich. Nature 448, 759-760.

• Featured in Primer by Kroemer and Blomgren. PLoS Biol 5(7): e206.

Spongiform neurodegeneration-associated E3 ligase Mahogunin ubiquitylates TSG101 and regulates endosomal trafficking.

Kim, B.Y.*, Olzmann, J.A.*, Barsh, G.S., Chin, L.S., Li, L. * Equal contribution.

Molecular Biology of the Cell. 2007. 18, 1129-1142.

Selective erichment of DJ-1 protein in primate striatal neuronal processes: Implications for Parkinson’s disease.

Olzmann, J.A., Bordelon, J.R., Muly, E.C., Rees, H.D., Levey, A.I., Li, L, Chin, L.S.

Journal of Comparative Neurology. 2007. 500, 585-599.

Oxidative damage of DJ-1 is linked to sporadic Parkinson's and Alzheimer's diseases.

Choi, J., Sullards, C. M., Olzmann, J. A., Rees, H. D., Weintraub, S. T., Bostwick, D. E., Gearing, M., Levey, A. I., Chin, L. S., Li, L.

Journal of Biological Chemistry. 2006. 281, 10816-24.

Uncoupling proteins prevent glucose-induced neuronal oxidative stress and programmed cell death.

Vincent, A. M., Olzmann, J. A., Brownlee, M., Sivitz, W. I., and Russell, J. W.

Diabetes. 2004. 53, 726-734.

Familial Parkinson's disease-associated L166P mutation disrupts DJ-1 protein folding and function.

Olzmann, J. A., Brown, K., Wilkinson, K. D., Rees, H. D., Huai, Q., Ke, H., Levey, A. I., Li, L., and Chin, L. S.

Journal of Biological Chemistry. 2004. 279, 8506-8515.

High glucose-induced oxidative stress and mitochondrial dysfunction in neurons.

Russell, J. W., Golovoy, D., Vincent, A. M., Mahendru, P., Olzmann, J. A., Mentzer, A., and Feldman, E. L.

FASEB Journal. 2002. 16, 1738-1748.​