PUBLICATIONS
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CLCC1 promotes hepatic neutral lipid flux and nuclear pore complex assembly
Mathiowetz, A., Meymand, E., Deol, K.D., Parlakgul, G., Lange, M., Pange, S.P., Roberts, M.A., Torres, E., Boone, C., Zhang, Y., Morgens, D.W., Tso, E., Zhou, Y., Talukdar, S., Levine, T.P., Ku, G., Arruda, A.P.#, Olzmann, J.A.# (Under review)
Preprint: https://www.biorxiv.org/content/10.1101/2024.06.07.597858v1
69
Ferroptosis in Health and Disease
Berndt, C., ..., Olzmann, J.A., ..., Conrad, M.
Redox Biology. (2024) 30:75:103211.
68
Lipid droplets and cellular lipid flux
Mathiowetz, A. and Olzmann, J.A.
Nature Cell Biology. (2024) 26(3):331-345.
67
The cell biology of ferroptosis
Dixon, S.J.# and Olzmann, J.A.#
Nature Reviews Molecular Cell Biology. (2024) 25(6):424-442.
66
Selenium reduction of ubiquinone via SQOR suppresses ferroptosis
Lee, N., Park, S.J., Lange, M., Tseyang, T., Doshi, M., Kwon, T.Y., Song, Y., Greer, P.L., Olzmann, J.A., Spinelli, J., Kim, D.
Nature Metabolism. (2024) 6(2):343-358.
– Featured in News & Views by Chambers and Ratan (Nature Metabolism. 2024)
Preprint: https://www.biorxiv.org/content/10.1101/2023.04.13.535674v1
65
Small molecule correctors divert CFTR-F508del from ERAD by stabilizing sequential folding states
Riepe, C., Wachalska, M., Deol, K.K. Amaya, K. Porteus, M.H., Olzmann, J.A., Kopito, R.R.
Molecular Biology of the Cell. (2024) 35(2):ar15.
Preprint: https://www.biorxiv.org/content/10.1101/2023.09.15.556420v1
64
Lipid quality control and ferroptosis: From concept to mechanism
Li, Z.*#, Lange, M.*, Dixon, S.J., Olzmann, J.A.#
Annual Review of Biochemistry. (2023) Online ahead of print.
63
Sensitization of cancer cells to ferroptosis coincident with cell-cycle arrest
Rodencal, J., Kim, N., He, A., Li, V.L., Lange, M., He, J., Tarangelo, A., Schafer, Z.T., Olzmann, J.A., Long, J.Z., Sage, J., Dixon, S.J.
Cell Chemical Biology. (2023) 31, 1–15. Online ahead of print.
Preprint: https://www.biorxiv.org/content/10.1101/2023.07.19.549715v1
62
Parallel CRISPR-Cas9 screens reveal mechanisms of PLIN2 and lipid droplet regulation
Roberts, M.A., Deol, K.K., Lange, M., Leto, D., Mathiowetz, A.J., Stevenson, J., Hashemi, S.H., Morgens, D.W., Easter, E., Heydari, K., Nalls, M.A., Bassik, M.C., Kampmann, M., Kopito, R.R., Faghri, F., Olzmann, J.A.
Developmental Cell. (2023) 18:S1534-5807(23)00331-3.
Preprint: https://www.biorxiv.org/content/10.1101/2022.08.27.505556v1
61
Identification of structurally diverse FSP1 inhibitors that sensitize cancer cells to ferroptosis
Hendricks, J.M., Doubravsky, C.E., Wehri, E., Li, Z., Roberts, M.A., Deol, K.K., Lange, M., Lasheras-Otero, I., Momper, J.D., Dixon, S.J., Bersuker, K., Schlatetzky, J.#, Olzmann, J.A.#
Cell Chemical Biology. (2023) 30(9):1090-1103.e7.
Preprint: https://www.biorxiv.org/content/10.1101/2022.12.14.520445v1
60
Protocol for performing pooled CRISPR-Cas9 loss of function screens to identify genetic modifiers
Mathiowetz, A.*, Roberts, M.A.*, Morgens, D.W., Olzmann, J.A.#, Li, Z.#
STAR Protocols. (2023) 4(2):102201.
59
Hydropersulfides are endogenous antioxidants that inhibit ferroptosis
Lange, M. and Olzmann, J.A.
Cell Chemical Biology. (2022) 29(12):1661-1663.
58
Genome-wide CRISPR screens implicate plasma membrane asymmetry in exogenous ceramide toxicity
Morris, S.N.S., Deol, K.K., Lange, M., Olzmann, J.A.
Biology Open. (2022) 11(12):bio059695.
Preprint: https://www.biorxiv.org/content/10.1101/2022.09.26.509629v1
57
VPS13A and VPS13C influence lipid droplet abundance
Chen, S.*, Roberts, M.A.*, Chen, C.Y., Markmiller, S., Wei, H.G., Yeo, G.W., Granneman, J.G., Olzmann, J.A.# Ferro-Novick, S.#
Contact. (2022) 5, 1-7.
Preprint: https://www.biorxiv.org/content/10.1101/2022.06.21.497109v1
56
Context-dependent regulation of ferroptosis sensitivity
Magtanong, L., Mueller, G.D., Williams, K.J., TKO Lab, Andrews, B., Boone, C., Moffat, J., Olzmann, J.A., Bensinger, S.J., Dixon, S.J.
Cell Chemical Biology. (2022) S2451-9456(22)00236-7.
– Featured in Preview by Lee and Gan (Cell Chem Biol. 2022)
55
End of the road: From the ER to the proteasome
Olzmann, J.A.
Nature Reviews Molecular Cell Biology. (2022) 23(8):520.
54
Ribosome stalling during selenoprotein translation exposes a ferroptosis vulnerability
Li, Z., Ferguson, L., Deol, K.K., Roberts, M.A., Magtanong, L., Hendricks, J.M., Mousa, G.A., Kilinc, S., Schaefer, K., Wells, J.A., Bassik, M.C., Goga, A., Dixon, S.J., Ingolia, N., Olzmann, J.A.
Nature Chemical Biology. (2022) 18(7):751-761.
Preprint: https://www.biorxiv.org/content/10.1101/2022.04.11.487892v1 – Featured in Research Watch (Cancer Discovery. 2022).
53
The Lipid Droplet Knowledge Portal: A resource for systematic analyses of lipid droplet biology
Mejhert N., Gabriel, K.R., Frendo-Cumbo, S., Krahmer, N., Song, J., Kuruvilla, L., Chitraju, C., Boland, S., Jang, D.K., von Grotthuss, M., Costanzo, M.C., Ryden, M., Olzmann, J.A., Flannick, J., Burtt, N.P., Farese, R.V., Walther, T.C.
Developmental Cell. (2022) 57, 387–397.
52
Olzmann, J.A., Fendt, S.M., Shah, Y., Vousden, K., Chandel, N., Horng, T., Danial, N., Tu, B., Christofk, H., Vander Heiden, M.G., Wellen, K.
Molecular Cell. (2021) 81(18):3659-3664.
51
Ending on a sour note: exogenous lipids orchestrate cancer cell death
Lange, M. and Olzmann, J.A.
Cell Metabolism. (2021) 33(8):1507-1509.
50
Peterson, C.W.H.*, Deol, K.K.*, To, M., Olzmann, J.A.
STAR Protocols. (2021) 5;2(2):100579.
49
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)
Klionsky, D., … Olzmann, J.A., et al.
Autophagy. (2021) 17(1):1-382.
48
Diversity through equity and inclusion: The responsibility belongs to all of us
Olzmann, J.A.
Mol. Biol. Cell. (2020) 31(25):2757-2760.
47
Protein quality control and lipid droplet metabolism
Roberts, M.A. and Olzmann, J.A.
Annu. Rev. Cell Dev. Biol. (2020) 36:115-139.
46
Organelle biogenesis: ER shape influences lipid droplet nucleation
Roberts, M.A., Segura-Roman, A., Olzmann, J.A.
Current Biol. (2020) 30(13), R770–R773.
45
Liang, J.R.*, Lingeman, E.*, Luong, T., Ahmed, S., Nguyen, T., Olzmann, J.A., Corn, J.
Cell. (2020) 180, 1–18. PMID: 32160526.
– Preprint: https://www.biorxiv.org/content/10.1101/561001v1
– Featured in Research Highlight by Paulina Strzyz (Nat. Rev. Mol. Cell Biol. 2020)
– Featured in Spotlight by Maurizio Molinari (Mol. Cell. 2020)
44
Li, Z., Morris, S.N.S., Olzmann, J.A.
Nature Chemical Biology. (2020) 16(2):111-112.
43
The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis
Bersuker, K., Hendricks, J., Li, Z., Magtanong, L., Ford, B., Tang, P.H., Roberts, M.A., Tong, B., Maimone, T.J., Zoncu, R., Nomura, D.K., Bassik, M.C., Dixon, S.J., Olzmann, J.A.
Nature. (2019) 575(7784):688-692.
– Featured in News & Views by Brent Stockwell (Nature. 2019)
– Featured in Research Highlight by Grant Miura (Nat. Chem. Biol. 2019)
– Featured in Research Highlight by Liang et al. (Cell Res. 2019)
– Featured in Preview by Massimo Santoro (Cell Metab. 2020)
– Featured in Viewpoint by Kamyar Hadian (Biochemistry 2020).
42
Chung C.Y.S., Shin, H.R., Berdan, C.A., Ford, B., Ward, C.C., Olzmann J.A., Zoncu, R., Nomura, D.K.
Nature Chemical Biology. (2019) 15(8):776-785.
41
A tense situation: Maintaining ER homeostasis during lipid droplet budding
Morris, S.N.S. and Olzmann, J.A.
Developmental Cell. (2019) 50, 1-2.
40
Harnessing the anti-cancer natural product nimbolide for targeted protein degradation
Spradlin, J.N., Hu, X., Ward, C.C., Brittain, S.M., Jones, M.D., Ou, L., To, M., Proudfoot, A., Ornelas, E., Woldegiorgis, M., Olzmann, J.A., Bussiere, D.E., Thomas, J.R., Tallarico, J.A., McKenna, J.M., Schirle, M., Maimone, T.J., Nomura, D.K.
Nature Chemical Biology. (2019) 15(7):747-755.
– Preprint: https://www.biorxiv.org/content/10.1101/436998v2
– Featured in News & Views by Brand and Winter (Nat. Chem. Biol. 2019)
39
Identification of lipid droplet proteomes by proximity labeling proteomics using APEX2
Bersuker, K. and Olzmann, J.A.
Methods Molecular Biology - Proximity Labeling. (2019) 57-72.
38
Berdan, C.A., Ho, R., Lehtola, H.S., To, M., Hu, X., Huffman, T.R., Petri, Y., Altobelli, C.R., Demeulenaere, S.G., Olzmann, J.A., Maimone, T.J., Nomura, D.K.
Cell Chemical Biology. (2019) 26(7):1027-1035. PMID: 31080076.
– Preprint: https://www.biorxiv.org/content/10.1101/550806v2
37
Getting a handle on lipid droplets: Insights into ER-lipid droplet tethering
Nguyen, T. and Olzmann J.A.
Journal of Cell Biology. (2019) 218(4):1089-1091.
36
Exogenous monounsaturated fatty acids suppress non-apoptotic cell death
Magtanong, L., Ko, P.J., To, M., Cao, J.Y., Tarangelo, A.N., Ward, C., Nomura, D.K., Olzmann, J.A., Dixon, S.
Cell Chemical Biology. (2019) 26, 420–432.
– Featured in Preview by Unduri Das (Cell Chem. Biol., 26, 309-311)
35
Dynamics and functions of lipid droplets
Olzmann, J.A.# and Carvalho, P.#
Nature Reviews Molecular Cell Biology. (2019) 20(3): 137-155.
34
A proteomic map to navigate subcellular reorganization in fatty liver disease
Li, Z. and Olzmann, J.A.
Developmental Cell. (2018) 47, 139-141.
33
In close proximity: The lipid droplet proteome and crosstalk with the ER
Bersuker, K. and Olzmann, J.A.
Contact. (2018) (1), 1-3.
32
Huang, E.Y.*, To, M.*, Tran, E., Dionisio, L., Cho, H.J., Baney, K.L.M., Pataki, C.I., Olzmann, J.A.
Molecular Biology of the Cell. (2018) 29(9), 1021-1030.
– Featured as an MBoC highlight.
– Featured on the cover of the journal.
31
Bersuker, K., Peterson, C.W., To, M., Sahl, S.J., Savikhin, V., Grossman, E.A., Nomura, D.K., Olzmann, J.A.
Developmental Cell. (2018) 44, 97-112.
– Featured in Preview by Joel Goodman (Dev. Cell, 44, 1-2)
30
Anderson, K.E., To, M., Olzmann, J.A., Nomura, D.K.
ACS Chemical Biology. (2017) 12(10), 2522-2528.
29
Lipid droplets and lipotoxicity during autophagy
Nguyen, T.B. and Olzmann, J.A.
Autophagy. (2017) 13:11, 2002-2003.
28
Nguyen, T.B., Louie, S.M., Daniele, J., Tran, Q., Dillin, A., Zoncu, R., Nomura, D.K., Olzmann, J.A.
Developmental Cell. (2017) 42, 9–21.
– Featured in Preview by Klecker et al. (Dev. Cell 41, 1-2)
– Featured in Comment by Li et al. (Autophagy 13, 1995-1997)
– Featured in Best of Dev. Cell 2017
27
Bersuker, K. and Olzmann, J.A.
BBA - Molecular and Cell Biology of Lipids. (2017) 1862(10 Pt B), 1166-1177.
26
Hwang, J., Walczak, C.P., Shaler, T.A., Olzmann, J.A., Zhang, L., Elias, J.E., Kopito, R.R.
Journal of Biological Chemistry. (2017) 292, 9104-9116.
25
Bateman, L.A., Nguyen, T.B., Roberts, A.M., Miyamoto, D.K., Ku, W.M., Huffman, T.R., Petri, Y., Heslin, M.J., Contreras, C.M., Skibola, C.F., Olzmann, J.A.#, Nomura, D.K.#
Chemical Communications. (2017) 53(53), 7234-7237.
24
To, M.*, Peterson, C.W.*, Roberts, M.A., Counihan, J.L., Wu, T.T., Forster, M.S., Nomura, D.K., Olzmann, J.A.
Molecular Biology of the Cell. (2017) (28), 270-284.
23
Endoplasmic reticulum-associated degradation and lipid homeostasis
Stevenson, J.*, Huang, E.Y.*, Olzmann, J.A.
Annual Review of Nutrition. (2016) 36, 17.1–17.32.
22
A polyubiquitin chain reaction: Parkin recruitment to damaged mitochondria
Riley, B.E., Olzmann, J.A.
PLOS Genet. (2015) 11(1), e1004952.
21
Spatial regulation of UBXD8 and p97/VCP controls ATGL-mediated lipid droplet turnover
Olzmann, J.A., Richter, C.R., Kopito, R.R.
Proc. Natl. Acad. Sci. (2013) 110(4), 1345-50.
20
The mammalian endoplasmic reticulum-associated degradation system
Olzmann, J.A., Kopito, R.R., Christianson, J.C.
Cold Spring Harb. Perspect. Biol. (2013) cshperspect.a013185v1. 1;5(9), pii: a013185.
– Featured on the cover of the journal.
19
Unassembled CD147 is an endogenous ER-associated degradation (ERAD) substrate
Tyler, R.E., Pearce, M.M.P., Shaler, T.A., Olzmann, J.A., Greenblatt, E.J., Kopito, R.R.
Mol. Biol. Cell. (2012) 23(24), 4668-78.
– Faculty of 1000 recommended.
18
Making the cut: Intramembrane cleavage by a rhomboid protease promotes ERAD
Greenblatt, E.J., Olzmann, J.A., Kopito, R.R.
Nature Struct. Mol. Biol. (2012) 19(10), 979-981.
– Faculty of 1000 recommended.
17
Defining human ERAD networks through an integrated mapping strategy
Christianson, J.C.*, Olzmann, J.A.*, Shaler, T.A., Sowa, M.E., Bennett, E.J., Richter, C.M., Tyler, R.E., Greenblatt, E.J., Harper, J.W., Kopito, R.R.
* These authors contributed equally.
Nature Cell Biol. (2012) 14(1), 93-105.
– Featured in News and Views by Thibault Mayor (Nat Cell Biol 14(1), 46-47)
– Faculty of 1000 recommended.
16
Greenblatt, E.J., Olzmann, J.A., Kopito, R.R.
Nature Struct. Mol. Biol. (2011) 18(10), 1147-1152.
15
Lee, S.M., Olzmann, J.A., Chin, L.S., Li, L.
J. Cell Sci. (2011) 124, 3319-3331.
14
Lipid droplets are dispensable for endoplasmic reticulum-associated degradation
Olzmann, J.A., Kopito, R.R.
J. Biol. Chem. (2011) 286, 27872-27874.
– Faculty of 1000 recommended.
13
Parkin-mediated ubiquitin signaling in aggresome formation and autophagy
Chin, L.S., Olzmann, J.A., Li, L.
Biochem. Soc. Trans. (2010) 48(1), 144-149.
12
Wang, Y., Pearce, M.M., Sliter, D.A., Olzmann, J.A., Christianson, J.C., Kopito, R.R., Boeckmann, S., Gagen, C., Leichner, G.S., Roitelman, J., Wojcikiewicz, R.J.
Biochim. Biophys. Acta. (2009) 1793(11), 1710-8.
11
Kim, B.Y., Olzmann, J.A., Choi, S.I., Ahn, S.Y., Kim, T.I., Cho, H.S., Suh, H., Kim, E.K.
J. Biol. Chem. (2009) 284,19580-19591.
10
Aggresome formation and neurodegenerative diseases: therapeutic implications
Olzmann, J.A., Li, L., Chin, L.S.
Curr. Med. Chem. (2008) 15(1), 47-60.
9
Olzmann, J.A., Chin, L.S.
Autophagy. (2008) 4(1), 85-87.
8
Parkin-mediated K63-linked polyubiquitination targets misfolded DJ-1 to aggresomes via binding HDAC6
Olzmann, J.A., Li, L., Chudaev, M., Perez, F.A., Palmiter, R. D., Chin, L.S.
J. Cell Biol. (2007) 178, 1025-1038.
7
Pridgeon, J.W.*, Olzmann, J.A.*, Chin, L.S., Li, L.
* These authors contributed equally.
PLOS Biol. (2007) 5, e172. PMID: 17579517.
– Featured in News and Views by Asa Abeliovich (Nature 448, 759-760)
– Primer by Kroemer and Blomgren (PLoS Biol 5(7): e206)
– Faculty of 1000 recommended.
6
Kim, B.Y.*, Olzmann, J.A.*, Barsh, G.S., Chin, L.S., Li, L.
* These authors contributed equally.
Mol. Biol. Cell. (2007) 18, 1129-1142. PMID: 17229889.
– Faculty of 1000 recommended.
5
Olzmann, J.A., Bordelon, J.R., Muly, E.C., Rees, H.D., Levey, A.I., Li, L, Chin, L.S.
J. Comp. Neurol. (2007) 500, 585-599.
4
Oxidative damage of DJ-1 is linked to sporadic Parkinson's and Alzheimer's diseases
Choi, J., Sullards, C.M., Olzmann, J.A., Rees, H.D., Weintraub, S.T., Bostwick, D.E., Gearing, M., Levey, A.I., Chin, L.S., Li, L.
J. Biol. Chem. (2006) 281, 10816-24.
3
Uncoupling proteins prevent glucose-induced neuronal oxidative stress and programmed cell death
Vincent, A.M., Olzmann, J.A., Brownlee, M., Sivitz, W.I., and Russell, J.W.
Diabetes. (2004) 53, 726-734.
2
Familial Parkinson's disease-associated L166P mutation disrupts DJ-1 protein folding and function
Olzmann, J. A., Brown, K., Wilkinson, K. D., Rees, H. D., Huai, Q., Ke, H., Levey, A. I., Li, L., and Chin, L. S.
J. Biol. Chem. (2004) 279, 8506-8515.
1
High glucose-induced oxidative stress and mitochondrial dysfunction in neurons
Russell, J.W., Golovoy, D., Vincent, A.M., Mahendru, P., Olzmann, J.A., Mentzer, A., and Feldman, E.L.
FASEB J. (2002) 16, 1738-1748.